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KMID : 0043319910140020143
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Archives of Pharmacal Research
1991 Volume.14 No. 2 p.143 ~ p.146
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An Efficient Synthetic Route to Chiral beta-Hydroxy-delta-lactone Moiety of Compactin
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Jahng YD
Kim JI
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Abstract
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A new synthetic sequence for the chiral lactone moiety of compactin was developed from alpha-D-glucose in 9 steps via simultaneous reductive detosylation and epoxide-ring opening of 2,3-epoxy-4-tosylate using NaBH4 to afford 2,4-dideoxy sugar as a key intermediate.
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KEYWORD
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